Description
Product Characteristics: The Biomedica human Osteoprotegerin (OPG/TNFRSF11B) Sandwich ELISA kit is a quick day test intended for the quantitative measurement of OPG levels in serum and plama samples (EDTA, citrate and heparin). The human OPG Sandwich ELISA is highly recognised with over 250 OPG ELISA specific references to date. Target Information: Osteoprotegerin (OPG) or osteoclast inhibitory factor (OCIF) is a glycoprotein of the TNF receptor superfamily 11b. OPG is synthesized as a monomer of 380 amino acids and is assembled as a homodimer within the cell, and then secreted mainly as a disulfide-linked homodimer into the extracellular compartment. OPG is produced by many different tissues and cell types including osteoblasts. OPG is a negative regulator of bone resorption by acting as decoy receptor for RANKL, thus neutralizing its function in osteoclastogenesis. This glycoprotein is also involved in the regulation of vascular calcification